ISSN 2394-5125
 

Research Article 


STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER

Olga A. Osipova, Elena V. Gosteva, Ruslan N. Shepel, & 1054;ksana N. Belousova, Larisa V. Tsurikova, Tatyana A. Petrichko.

Abstract
Of particular interest is the study of the mechanisms of development of chronic heart failure (CHF), especially with middle range ejection fraction in elderly patients.65 patients were examined (40 men, 25 women), age 66.7 4.3 years, with chronic heart failure middle range ejection fraction (HFmrEF), NYHA class II, control group (CG) - 30 age-comparable individuals without signs of heart failure. The concentration in the blood of oxidized low-density lipoproteins (OxLDL) in patients with HFmrEF (112.3 (96.3; 123.6) ng/ml) is 98% higher than CG; women are 19% higher than men. The value of general oxidizing ability of the blood in the study group is 2.71 (2.38; 2.90) μmol/L, which is 51% higher than CG; in women it is 14% higher. In the HFmrEF group, the values of general antioxidant activity of blood are 40.7 (35.2; 50.7) μmol/L, which is 29%, lower than CG, in women 24% higher than men. The content of superoxide dismutase in patients with HFmrEF (0.54 (0.43; 0.71) ng/ml), which is 44% lower than CG, in women 25% higher. The level of interleukin-1β (interleukine) in HFmrEF patients (2.84 (2.35; 3.42) pg/ml) is 135% higher than CG, in women it is higher by 31%. The content of interleukin-6 in the blood of patients with HFmrEF (6.18 (5.38; 6.78) pg/ml), which is 2.27 times higher than CG, and interleukin-8 in patients with HFmrEF (22.6 (20, 3; 24.4) pg/ml) 6.38 times higher than СG. No gender differences were found. The level of tumor necrosis factor-α in the HFmrEF group is 3.49 times higher (14.02 (11.34; 15.37) pg/ml) than KG, in women it is 26% higher. The level of interleukin-4 in the HFmrEF group in women is 24% higher than men. In elderly patients with HFmrE, a state of oxidative stress, a decrease in antioxidant defense, an increase in immune inflammation, especially pronounced in women, were revealed.

Key words: elderly patients, chronic heart failure middle range ejection fraction, oxidative stress, antioxidant protection, immune inflammation, gender


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Olga A. Osipova
Articles by Elena V. Gosteva
Articles by Ruslan N. Shepel
Articles by & 1054;ksana N. Belousova
Articles by Larisa V. Tsurikova
Articles by Tatyana A. Petrichko
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

, . STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. JCR. 2020; 7(15): 14-21. doi:10.31838/jcr.07.15.03


Web Style

, . STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. http://www.jcreview.com/?mno=119262 [Access: June 27, 2020]. doi:10.31838/jcr.07.15.03


AMA (American Medical Association) Style

, . STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. JCR. 2020; 7(15): 14-21. doi:10.31838/jcr.07.15.03



Vancouver/ICMJE Style

, . STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. JCR. (2020), [cited June 27, 2020]; 7(15): 14-21. doi:10.31838/jcr.07.15.03



Harvard Style

& (2020) STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. JCR, 7 (15), 14-21. doi:10.31838/jcr.07.15.03



Turabian Style

, and ksana N. Belousova, Larisa V. Tsurikova, Tatyana A. Petrichko. 2020. STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. Journal of Critical Reviews, 7 (15), 14-21. doi:10.31838/jcr.07.15.03



Chicago Style

, and ksana N. Belousova, Larisa V. Tsurikova, Tatyana A. Petrichko. "STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER." Journal of Critical Reviews 7 (2020), 14-21. doi:10.31838/jcr.07.15.03



MLA (The Modern Language Association) Style

, and ksana N. Belousova, Larisa V. Tsurikova, Tatyana A. Petrichko. "STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER." Journal of Critical Reviews 7.15 (2020), 14-21. Print. doi:10.31838/jcr.07.15.03



APA (American Psychological Association) Style

& (2020) STUDY OF THE ROLE OF OXIDATIVE STRESS, ANTIOXIDANT PROTECTION AND IMMUNE INFLAMMATION MARKERS IN THE PATHOGENESIS OF CHRONIC HEART FAILURE BY THE MIDDLE RANGE EJECTION FRACTION IN ELDERLY PATIENTS DEPENDING ON GENDER. Journal of Critical Reviews, 7 (15), 14-21. doi:10.31838/jcr.07.15.03