ISSN 2394-5125
 

Research Article 


EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Arash Abbasi, Mahnaz Momenzadeh*, Toktam Salehi.

Abstract
trials that designed to best treating post-traumatic depression are rare, so it is important to treating
post-TBI depression. The aim of present Systematic Review and Meta-analysis was determine the Effectiveness
of pharmacological and non-pharmacological interventions for depression in patients with moderate-to-severe
traumatic brain injury.From the electronic databases, PubMed, Cochrane Library, Embase, ISI have been used to
perform a systematic literature between 2010 and 2020. Therefore, a software program (Endnote X8) has been
utilized for managing the electronic titles. Searches were performed with mesh terms. mean differences between
two groups (pharmacological and non-pharmacological interventions) with 95% confidence interval (CI), fixed
effect model and Inverse-variance method were calculated. Random effects were used to deal with potential
heterogeneity and I2 showed heterogeneity. The Meta analysis and forest plots have been evaluated with the use
of a software program available in the market (i.e., Comprehensive Meta-Analysis Stata V16).A total of 86
potentially relevant titles and abstracts were found during the electronic and manual search. Finally, a total of six
publications fulfilled the inclusion criteria required for this systematic review. Mean difference was (MD, -1.14
95% CI -2.35, 0.08. P= 0.07) and heterogeneity found (I2 = 62.68%; P =0.07), this result showed there was no
statistically significant difference of post-intervention outcomes between control group and intervention group
(p=0.07). Also Mean difference to compared Post-intervention outcomes between control group and intervention
group was (MD, -0.54 95% CI -2.71, 1.63. P= 0.63) among 3 studies and heterogeneity found (I2 = 62.68%; P
=0.62The present study shows a positive effect of both pharmacological and non-pharmacological methods to
reduce depression after TBI.

Key words: pharmacological, non-pharmacological, depression, traumatic brain injury


 
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Pubmed Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. JCR. 2020; 7(15): 101-111. doi:10.31838/jcr.07.15.15


Web Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. http://www.jcreview.com/?mno=119293 [Access: June 27, 2020]. doi:10.31838/jcr.07.15.15


AMA (American Medical Association) Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. JCR. 2020; 7(15): 101-111. doi:10.31838/jcr.07.15.15



Vancouver/ICMJE Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. JCR. (2020), [cited June 27, 2020]; 7(15): 101-111. doi:10.31838/jcr.07.15.15



Harvard Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi (2020) EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. JCR, 7 (15), 101-111. doi:10.31838/jcr.07.15.15



Turabian Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. 2020. EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal of Critical Reviews, 7 (15), 101-111. doi:10.31838/jcr.07.15.15



Chicago Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. "EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS." Journal of Critical Reviews 7 (2020), 101-111. doi:10.31838/jcr.07.15.15



MLA (The Modern Language Association) Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi. "EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS." Journal of Critical Reviews 7.15 (2020), 101-111. Print. doi:10.31838/jcr.07.15.15



APA (American Psychological Association) Style

Arash Abbasi, Mahnaz Momenzadeh, Toktam Salehi (2020) EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS FOR DEPRESSION IN PATIENTS WITH MODERATE-TOSEVERE TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal of Critical Reviews, 7 (15), 101-111. doi:10.31838/jcr.07.15.15





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