ISSN 2394-5125
 

Research Article 


TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov.

Abstract
Background: Cardiovascular diseases (CVD) have currently secured a leading position in the
structure of morbidity and mortality in the world. Aim of the study was to investigate the frequency of
polymorphic alleles and genotypes of the TNF-α rs1800630 gene promoter and 174 G/C polymorphism of the
IL6 gene in the blood of healthy individuals and patients with coronary artery disease (CAD) in Uzbek
population.
Methods: 53 patients with CAD and angina pectoris II-III functional classes were enrolled in this study. All
laboratory, instrumental and genetic analysis were obtained and all statistical analysis performed by
STATISTICA 10 software and data were expressed as mean (SD).
Results: It was found that carriers of the mutant and heterozygous genotypes AA and CA were 7.5% (n=4),
healthy СС genotype predominated (85%, n=45). There were no differences in the group of patients with CAD
and healthy subjects when analyzing the C-863-A polymorphism of the TNFα gene. When analyzing the
genotyping of the polymorphism (174 G/C) of the IL-6 gene in the group of patients with CAD, carriers of the
mutant CC genotype were 9% (n=17), the prevalence of the heterozygous genotype GС (51%, n=27), and
carriers of the wild GG genotype were detected in 32% (n=17). Distribution of genotypes in patients with CAD
revealed that the GG genotype significantly decreased in patients with CAD relative to healthy individuals.
Conclusion: The identification of molecular markers of systemic inflammation can be used to assess a
personalized prognosis of the development and progression of coronary artery disease.

Key words: cardiovascular disease; coronary artery disease; genotype


 
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How to Cite this Article
Pubmed Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. JCR. 2020; 7(19): 5505-5412. doi:10.31838/jcr.07.19.639


Web Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. http://www.jcreview.com/?mno=133463 [Access: September 14, 2020]. doi:10.31838/jcr.07.19.639


AMA (American Medical Association) Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. JCR. 2020; 7(19): 5505-5412. doi:10.31838/jcr.07.19.639



Vancouver/ICMJE Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. JCR. (2020), [cited September 14, 2020]; 7(19): 5505-5412. doi:10.31838/jcr.07.19.639



Harvard Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov (2020) TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. JCR, 7 (19), 5505-5412. doi:10.31838/jcr.07.19.639



Turabian Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. 2020. TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. Journal of Critical Reviews, 7 (19), 5505-5412. doi:10.31838/jcr.07.19.639



Chicago Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. "TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE." Journal of Critical Reviews 7 (2020), 5505-5412. doi:10.31838/jcr.07.19.639



MLA (The Modern Language Association) Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov. "TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE." Journal of Critical Reviews 7.19 (2020), 5505-5412. Print. doi:10.31838/jcr.07.19.639



APA (American Psychological Association) Style

Anis Alyavi, Baxrom Alyavi, Dildora Tulyaganova, Zulfiya Sabirjanova, Sevara Nuritdinova, Nasima Kayumova, Tatayana Khan, Gulchehra Nazarova, Djamshida Imankulova, Jamol Uzokov (2020) TUMOR NECROSIS FACTOR-α AND INTERLEUKIN6 GENE DISTRIBUTION IN PATIENTS WITH CORONARY HEART DISEASE. Journal of Critical Reviews, 7 (19), 5505-5412. doi:10.31838/jcr.07.19.639