ISSN 2394-5125
 

Review Article 


FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET

Gaurav Bhaduka, Jitendra Singh Rajawat.

Abstract
The objective of the present investigation was to development of formulation, in vitro and in vivo characterization of low water soluble voriconazole as a model drug. Initially, the solubility of voriconazole was enhanced by fabricating the solid dispersion using Gelucire® 44/14 and polaxamer 188 using combined hot melt and solvent evaporation method. The voriconazole tablets were fabricated by wet granulation techniques and the different quality control parameters of tablets were evaluated. The in vitro release characteristics of tablets were evaluated. Tablet formulation that exhibited faster release was considered for stability studies and in vivo pharmacokinetics evaluation. The tablets of entire formulations had passed the USP criteria for quality control tests of tablets. The in vitro release profile of tablets was found to release the drug within 105 minutes. The in vivo pharmacokinetic parameters designated the enhancement of oral bioavailability of voriconazole from fabricated tablets in rabbit as compared to drug suspension. The tablet formulation was found stable upto 3 months at accelerated stability conditions and enhancement of oral bioavailability of voriconazole from tablet formulation was observed. It can be concluded that the fabricated voriconazole tablet is having promising potential for enhancement of therapeutic prospective of voriconazole.

Key words: Solid dispersions; Voriconazole; Gelucire® 44/14; Polaxamer 188; tablets; in vitro and in vivo characterization.


 
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Pubmed Style

Gaurav Bhaduka, Jitendra Singh Rajawat. FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. JCR. 2020; 7(2): 117-123. doi:10.31838/jcr.07.02.22


Web Style

Gaurav Bhaduka, Jitendra Singh Rajawat. FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. http://www.jcreview.com/?mno=86251 [Access: September 15, 2020]. doi:10.31838/jcr.07.02.22


AMA (American Medical Association) Style

Gaurav Bhaduka, Jitendra Singh Rajawat. FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. JCR. 2020; 7(2): 117-123. doi:10.31838/jcr.07.02.22



Vancouver/ICMJE Style

Gaurav Bhaduka, Jitendra Singh Rajawat. FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. JCR. (2020), [cited September 15, 2020]; 7(2): 117-123. doi:10.31838/jcr.07.02.22



Harvard Style

Gaurav Bhaduka, Jitendra Singh Rajawat (2020) FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. JCR, 7 (2), 117-123. doi:10.31838/jcr.07.02.22



Turabian Style

Gaurav Bhaduka, Jitendra Singh Rajawat. 2020. FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. Journal of Critical Reviews, 7 (2), 117-123. doi:10.31838/jcr.07.02.22



Chicago Style

Gaurav Bhaduka, Jitendra Singh Rajawat. "FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET." Journal of Critical Reviews 7 (2020), 117-123. doi:10.31838/jcr.07.02.22



MLA (The Modern Language Association) Style

Gaurav Bhaduka, Jitendra Singh Rajawat. "FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET." Journal of Critical Reviews 7.2 (2020), 117-123. Print. doi:10.31838/jcr.07.02.22



APA (American Psychological Association) Style

Gaurav Bhaduka, Jitendra Singh Rajawat (2020) FORMULATION DEVELOPMENT AND IN VITRO IN VIVO CHARACTERIZATION OF VORICONAZOLE TABLET. Journal of Critical Reviews, 7 (2), 117-123. doi:10.31838/jcr.07.02.22