Abstract

Myxedema is related to a severe form of hypothyroidism, which is a condition where thyroid gland does not have the capability to secrete enough thyroid hormones. Causes of myxedema are primary hypothyroidism a n d secondary hypothyroidism. Treatment is linked to radiation injury, genetic factors and rare conditions such as Riedes thyroiditis as well as Sheehans syndrome, Symptoms of myxedema incl ude fatigue, weakness, cold intolerance, weight gain, constipation, bradycardia and hoarseness of voice. Physical signs of myxedema are peri orbital puffiness, coarse facial features, n0n pitting edema of hands as well as feet. Cardio vascular symptoms o f myxedema include bradycardia, high blood pressure and decreased cardiac output. Diagnosis is based on physical examination as well as clinical presentation. Names of laboratory tests include thyroid function tests, thyroid antibodies as well as imaging studies. Other diagnostic tests are lipid profile. Electro cardio gram and fine needle aspiration. Differential diagnosis is related to other causes of edema like heart failure, nephrotic syndrome, liver disease, Hashimotos thy rooiditis, pre tibial myxedema, obesity, cushings syndrome and auto immune disorders. Treatment is based on hormone replacement therapy that is levothyroxine, Liothyronine, supportive care like intra venous thyroid hormone, elect rolytes as well as fluid balance. It is finally concluded that myxedema is a serious medical condition occurred by severe hypothyroidism and it is manifested by extreme fatigue, cold intolerance, dry skin and mental sluggis hness.

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