ISSN 2394-5125
 
2021, Vol: 8, Issue: 8
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    PREPARATION AND CHARACTERISATION OF CUMIN SEED OIL EXTRACT PHYTOSOMAL GEL (2019)
    Amol A. Ban, Samrat A. Khedkar, Swapnil R. Nazarkar, Rajendra G. Kharade, Rachana S. Das
    JCR. 2019: 907-911

    Abstract

    Phytosomes containing vesicular drug delivery system wherein phytoconstituents of herb extract nearby and bound by lipid (one phyto-constituent molecule linked with at least one phospholipid molecule) Thymoquinone is the main active constituent of Cumin seed oil. Using Design of experiment 5 different formulations were prepared. Two different independent variables were used which include: Amount of lipids (F1), Amount of cholesterol (F2). All the formulations was prepared using thin film hydration method. The Thymoquinone was more soluble in Methanol than in Ethanol, phosphate buffer pH 7.4 and water. The prepared thymoquinone was subject to the %EE. The highest entrapment efficiency was found to be 90.8 � 0.6 % which is selected as optimized formulation and evaluated for Homogenicity, spreadability, pH, Viscosity, Stability.

    Description

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    Volume & Issue

    Volume 6 Issue-7

    Keywords

    Thymoquinone, Phytosome, Phospholipid.
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