Abstract

2-substituted benzimidazole derivatives were prepared by different substituted orthophenelediamine and substituted chloro-benzoic acid which are evaluated for cytotoxic activity. The compounds where synthesize from orthophenelediamine and were characterize by spectral analysis i.e., IR, 1HNMR and mass spectrometry. all novel synthesizes derivativities code D1- D6 were further evaluated for cytotoxic activity using brine shrimp lethality bioassay. The molecular docking studies were performed by using VLife-MDS 4.3 software. Derivative code D3 exhibited good docking results of -39.5844 than the standard drug bendamustin. The cytotoxic activity and docking results of all synthesize derivatives shows that derivative D3 has more promising results at 5-FGK receptor and while comparing docking results of all derivatives to standard drug highlight the fact that synthesize derivatives considered as possible hit as therapeutic agents.

Description