ISSN 2394-5125
 

Research Article 


OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS

K. Nithya, T. Angeline.

Abstract
Type 2 diabetes mellitus is a polygenic and multifactorial disease which is considered as the most common form of diabetes rising alarmingly throughout the world in the recent times. The interesting fact is that the chronic hyperglycemia in diabetes itself leads to increased oxidative stress, which may result in oxidative DNA damage. In addition to that, the genetic polymorphisms in the folate metabolic pathway play a critical role in the etiology of diabetes and its complications. The development of complications is mainly due to excessive generation of free radicals that could ultimately result in DNA damage. Evidence also suggests that aberrations in folate metabolism may induce oxidative DNA damage in diabetes mellitus. In this fascinating background, this chapter was designed to elucidate the role of oxidative stress and polymorphisms involved in the folate metabolic pathway and its association with Type 2 diabetes mellitus.

Key words: Oxidative stress, Hyperglycemia, Reactive Oxygen Species, Antioxidants, DNA damage, Polymorphism, Folate metabolism, Methylenetetrahydrofolatereductase, Methionine synthase, Reduced folate carrier, Glutamate carboxypeptidase, Type 2 diabetes mellitus


 
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Pubmed Style

K. Nithya, T. Angeline. OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. JCR. 2021; 8(2): 339-350. doi:10.31838/jcr.08.02.38


Web Style

K. Nithya, T. Angeline. OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. http://www.jcreview.com/?mno=71630 [Access: April 17, 2021]. doi:10.31838/jcr.08.02.38


AMA (American Medical Association) Style

K. Nithya, T. Angeline. OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. JCR. 2021; 8(2): 339-350. doi:10.31838/jcr.08.02.38



Vancouver/ICMJE Style

K. Nithya, T. Angeline. OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. JCR. (2021), [cited April 17, 2021]; 8(2): 339-350. doi:10.31838/jcr.08.02.38



Harvard Style

K. Nithya, T. Angeline (2021) OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. JCR, 8 (2), 339-350. doi:10.31838/jcr.08.02.38



Turabian Style

K. Nithya, T. Angeline. 2021. OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. Journal of Critical Reviews, 8 (2), 339-350. doi:10.31838/jcr.08.02.38



Chicago Style

K. Nithya, T. Angeline. "OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS." Journal of Critical Reviews 8 (2021), 339-350. doi:10.31838/jcr.08.02.38



MLA (The Modern Language Association) Style

K. Nithya, T. Angeline. "OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS." Journal of Critical Reviews 8.2 (2021), 339-350. Print. doi:10.31838/jcr.08.02.38



APA (American Psychological Association) Style

K. Nithya, T. Angeline (2021) OXIDATIVE STRESS AND GENETIC POLYMORPHISMS IN THE FOLATE METABOLIC PATHWAY AND ITS ASSOCIATION WITH TYPE 2 DIABETES MELLITUS. Journal of Critical Reviews, 8 (2), 339-350. doi:10.31838/jcr.08.02.38