ISSN 2394-5125
 

Research Article 


PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh.

Abstract
BACKGROUND: Prothrombin time (PT) is used for assessment of extrinsic and common pathway of
coagulation; whereas activated partial thromboplastin time (APTT) assesses the intrinsic and common pathway.
Variation in blood group phenotypes has been linked to various diseases and their predisposition.
OBJECTIVE: The key objective of this study was to correlate the prothrombin time (PT) and activated partial
thromboplastin time (APTT) variations among different ABO blood group types.
METHODOLOGY: This study was cross-sectional, prospective carried out at Department of Pathology and
Medicine, Indus Medical College Tando Muhammad Khan for period of 8 months (February 2020 to September
2020). Total of 155 healthy participants were selected in this study. Individuals having bleeding history,
medication and co-morbid conditions were excluded from the study. After informed consent, 5mL of whole
blood was extracted from every participant to evaluate the coagulation profile and ABO blood group phenotype.
SPSS 24.0 was used for analysis of data. A p-value of <0.05 was taken as statistically significant.
RESULTS: Of 155 participants, 59 (38.06%) were having O blood group, 45 (29.03%) were having A blood
group, 31 (20%) were having B blood group and 20 (12.9%) were having AB blood groups. While comparing
the coagulation parameters among various blood groups, prothrombin time (PT) was shown to be highest in
individuals with A blood group in comparison of other blood group phenotypes; while activated partial
thromboplastin time (APTT) was highest in individuals with O blood group in comparison of other blood
groups, with statistically significant p-value.
CONCLUSION: The study showed that prothrombin time (PT) and activated partial thromboplasltin time
(APTT) vary in various blood group phenotypes. Blood group may influence their levels and mechanisms of
extrinsic and intrinsic pathways.

Key words: Prothrombin time, Activated partial thromboplastin time, blood groups, phenotypes, coagulation pathway.


 
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How to Cite this Article
Pubmed Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. JCR. 2021; 8(2): 1727-1731. doi:10.31838/jcr.08.02.173


Web Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. http://www.jcreview.com/?mno=98542 [Access: July 17, 2021]. doi:10.31838/jcr.08.02.173


AMA (American Medical Association) Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. JCR. 2021; 8(2): 1727-1731. doi:10.31838/jcr.08.02.173



Vancouver/ICMJE Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. JCR. (2021), [cited July 17, 2021]; 8(2): 1727-1731. doi:10.31838/jcr.08.02.173



Harvard Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh (2021) PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. JCR, 8 (2), 1727-1731. doi:10.31838/jcr.08.02.173



Turabian Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. 2021. PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. Journal of Critical Reviews, 8 (2), 1727-1731. doi:10.31838/jcr.08.02.173



Chicago Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. "PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES." Journal of Critical Reviews 8 (2021), 1727-1731. doi:10.31838/jcr.08.02.173



MLA (The Modern Language Association) Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh. "PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES." Journal of Critical Reviews 8.2 (2021), 1727-1731. Print. doi:10.31838/jcr.08.02.173



APA (American Psychological Association) Style

Shahzad Ali Jiskani, Razia Bano, Ali Akbar Pirzado, Asadullah Hanif, Abdul Ghafar Pirzado,Dolat Singh (2021) PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES. Journal of Critical Reviews, 8 (2), 1727-1731. doi:10.31838/jcr.08.02.173