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    FORMULATION AND EVALUATION FOR DISTRIBUTION OF FREE FLOATING MATRIX TABLETS USING IN ANTI-PARKINSONISM (2020)


    Lokeswara Babu V, Sunil Kumar Prajapati
    JCR. 2020: 3049-3057

    Abstract

    The present research attempted for improving the gastric residence time of pramipexole dihydrochloride to release drug slowly for about 24 h. Various excipients with different ratios were used to formulate sustained FDDS in tablet dosage form. The tablets were formulated by direct compression method with different grades of Hydroxy propyl methyl cellulose (HPMC) and carbopol as rate retarding polymers and a combination of sodium bi- carbonate and citric acid as gas generating system. Floating lag time, float- ing time, swelling index and in vitro drug release were determined in 0.1N HCl at 37�0.5 ?C. All formulations were evaluated for friability, weight variation, hardness, drug content uniformity, floating capacity and swelling index. The blend of HPMC K100 M and HPMC K15 M at 110 and 40 mg respectively shown excellent release upto 24h in F 9 and in F 8 containing HPMC K100 M and HPMC K15 M were 100 and 50 mg in the absence of MCC. The compatibility studies revealed by FTIR and DSC were also in good agreement; the accelerated stability studies have shown no significant change in drug release after 90 days. The increase in gastric residence time and prolonged drug release of a highly water-soluble drug like pramipexole could be achieved by formulating into matrix type floating drug delivery system

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    Volume & Issue

    Volume 7 Issue-6

    Keywords