HEPATOPROTECTIVE EFFECT OF CHITRAKAPIPPALI GHRITA IN PARACETAMOL INDUCED HEPATOTOXICITY- AN IN VIVO STUDY (2020)
Dr VIJITHA R KURUP. BAMS, MD JCR. 2020: 2210-2215
42 male Wistar rats were divided into 7 equal groups as follows. All drugs were administered orally. Group I: Untreated group. Group II: Control group, paracetamol (3gm/kg body weight of animal) for 1 day after over night fasting. Group III: Low dose CP (chitrakapippali ghrita) for 5 days, 6th day- CP(low dose) followed by paracetamol and on 7th day- CP(low dose) alone. Group IV: Therapeutic/intermediate dose CP for 5 days, 6th day- CP(intermediate dose) followed by paracetamol and on 7th day- CP(intermediate dose) alone. Group V: High dose CP for 5 days, 6th day- CP(high dose) followed by paracetamol and on 7th day- CP(high dose)only. Group VI: Silymarin (100mg/kg body weight of animal) for 5 days, 6th day- silymarin followed by paracetamol and on 7th day-silymarin alone. Group VII: High dose CP alone for 7 days. Biochemical parameters such as serum bilirubin, ALT, AST, ALP, albumin globulin ratio were analysed for the estimation of hepatotoxicity. RESULT: The animals treated with paracetamol showed significant elevation in serum parameters especially bilirubin, AST, ALT and a slight elevation in ALP when compared to other groups. Animals treated with CP at therapeutic and low doses show hepatoprotectivity in a dose dependant manner. The therapeutic/intermediate dose of CP was proved to have the most hepatoprotective effect through the estimation of serum parameters, and histopathological observations even than silymarin when serum ALT, AST are considered; bilirubin remains the same.
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