Abstract

This study examined the potential predictive value of urine levels of N-terminal pro-brain natriuretic peptide (NT-pro BNP) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) for bronchopulmonary dysplasia (BPD) in preterm newborns. Of the 84 preterm children participating in this prospective cohort trial, 70 went on to develop BPD. We assessed the levels of NT-proBNP and 8-OHdG in the urine between day 7 and day 28 of life. Next, we used correlations between the two biomarkers and receiver operating characteristic curves to evaluate the prediction efficiency. Between DOL 7 and 28, the BPD group's levels of 8-OHdG and NT-pro BNP were much greater than those of the control group (P < 0.05). Furthermore, from DOL7 to DOL28, there was a significant correlation between the 8-OHdG level and the NT-proBNP level (P < 0.001), as well as a positive correlation between the 8-OHdG and NT-proBNP levels and the length of mechanical ventilation and oxygen exposure time (P < 0.05). Furthermore, there was a strong correlation (P < 0.05) between the development of BPD and the levels of NT-proBNP (DOL 7-28) and 8-OHdG (DOL 14-28). Urine 8-OHdG concentrations from DOL 14 to 28 and NT-pro BNP concentrations from DOL 7 to 28 may serve as useful non-invasive indicators of the development of BPD in preterm children.

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