Synthesis and identification of morpholinium-5-amino-1,3,4-thiadiazole-2-thiolate, and study of the biological activity of some of their Schiff bases (2023)
Noora Abdul Rahman, Mukhlif Mohsin Slaihim JCR. 2023: 12-20
new series of morpholinium-5-amino-1,3,4-thiadiazole-2-thiolate salts (M1-M10) was produced by reacting different benzaldehyde derivatives with 5-amino-1,3,4-thiadiazole-2-thiol in the presence of morpholine. Infrared spectroscopy was used to evaluate our new Schiff bases of morpholinium-5-amino-1,3,4-thiadiazole-2-thiolate salts, and nuclear magnetic resonance spectroscopy and GC-MS were used to characterise some of them. The biological activity of the produced compounds was tested as an antibacterial against four species of bacteria, two of which are Gram-negative (Pseudomonas aeruginosa and Klebcellacoccus) and two of which are Gram-positive (Staphylococcus aureus and Streptococcus).
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